Document Detail

Rocuronium for nonemergent intubation of term and preterm infants.
MedLine Citation:
PMID:  20539274     Owner:  NLM     Status:  In-Process    
OBJECTIVE: The aim of this study was to analyze clinical characteristics of rocuronium as premedication for nonemergent intubation in infants.
STUDY DESIGN: Preterm infants requiring nonemergent intubation were randomized to receive atropine and fentanyl with or without rocuronium. Outcomes, patient characteristics and intubator's experience were noted. Onset, duration and degree of clinical paralysis were recorded for rocuronium group and for older infants receiving rocuronium per unit protocol.
RESULT: Forty-four intubations were randomized (20 rocuronium, 24 control). Groups were similar in chronological and corrected gestational age, weight and intubator's experience. Successful intubation on first attempt was achieved in 35% of intubations under rocuronium vs 8% of controls; rocuronium was the only significant variable by logistic regression (odds ratio=0.052, P=0.029). Complete paralysis was reported in 80% of 57 rocuronium intubations; onset ranged from 14 to 178 s (65.9±43.4), and duration from 1 to 60 min (16.3±13.5).
CONCLUSION: Rocuronium facilitated successful intubation and provided clinical paralysis quickly in most infants.
D M Feltman; M G Weiss; P Nicoski; J Sinacore
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Publication Detail:
Type:  Journal Article     Date:  2010-06-10
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  31     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-43     Citation Subset:  IM    
Division of Neonatology, Department of Pediatrics, Loyola University Medical Center, Maywood, IL, USA.
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