| Rocks: multifunctional kinases in cell behaviour. | |
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MedLine Citation:
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PMID: 12778124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states. |
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Authors:
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Kirsi Riento; Anne J Ridley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: 4 ISSN: 1471-0072 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-02 Completed Date: 2003-07-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 446-56 Citation Subset: IM |
Affiliation:
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Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK. kirsi@ludwig.ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Gene Expression Regulation* Humans Insulin / metabolism Intracellular Signaling Peptides and Proteins Models, Biological Muscle, Smooth / metabolism Phagocytosis Phosphorylation Phylogeny Protein Isoforms Protein-Serine-Threonine Kinases / metabolism, physiology* Signal Transduction rho-Associated Kinases |
| Chemical | |
Reg. No./Substance:
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0/Intracellular Signaling Peptides and Proteins; 0/Protein Isoforms; 11061-68-0/Insulin; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/rho-Associated Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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