| Robustly measuring vascular reactivity differences with breath-hold: normalising stimulus-evoked and resting state BOLD fMRI data. | |
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MedLine Citation:
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PMID: 20682354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inter-subject differences in local cerebral blood flow (CBF) and cerebral blood volume (CBV) contribute to differences in BOLD signal reactivity and, therefore, unmodelled variance in group level fMRI analyses. A simple way of elevating blood CO(2) concentrations to characterise subject differences in vascular reactivity is through breath-holds but two aspects of this measure are often neglected: (1) breath-holds are usually modelled as blocks even though CO(2) accumulates over time and (2) increases in CO(2) differ between subjects. This study demonstrates that the BOLD breath-hold response is best modelled by convolving the end-tidal CO(2) trace with a standard haemodynamic response function and including its temporal derivative. Inclusion of the BOLD breath-hold response as a voxel-dependent covariate in a group level analysis increases the spatial extent of activation in stimulus evoked and resting state datasets. By expressing the BOLD breath-hold response as a percentage signal increase with respect to an absolute change in the partial pressure of CO(2) (expressed in mmHg), the spatial extent of stimulus-evoked activation is further improved. This demonstrates that individual end-tidal CO(2) increases to breath-hold should be accounted for to provide an accurate measure of vascular reactivity resulting in more statistically active voxels in group level analyses. |
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Authors:
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Kevin Murphy; Ashley D Harris; Richard G Wise |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-01 |
Journal Detail:
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Title: NeuroImage Volume: 54 ISSN: 1095-9572 ISO Abbreviation: Neuroimage Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-10-22 Completed Date: 2011-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 369-79 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK. murphyk2@cardiff.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Blood Volume Brain / physiology Brain Mapping Breath Tests Carbon Dioxide / blood* Cerebrovascular Circulation / physiology* Humans Magnetic Resonance Imaging / methods* Maximal Voluntary Ventilation / physiology Oxygen / blood Regression Analysis Respiratory Mechanics / physiology Rest / physiology Tidal Volume |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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