Document Detail

Robust quantification of contrast agent (CA) concentration with magnetic field correlation (MFC) imaging.
MedLine Citation:
PMID:  19672949     Owner:  NLM     Status:  MEDLINE    
Contrast-enhanced perfusion studies of the brain by means magnetic resonance imaging (MRI) are used to estimate a number of important brain tissue parameters, including cerebral blood flow and volume. In order to calculate these parameters, the contrast agent (CA) concentration must first be estimated. This is usually accomplished by measurement of a nuclear magnetic resonance (NMR) relaxation rate with the assumption of a linear relationship between the rate and the CA concentration. However, such a linear relationship does not necessarily hold in biological tissues due to compartmentalization of the CA in either the intravascular or extracellular spaces. Here we propose an alternative MRI method of CA quantification based on measurement of the magnetic field correlation (MFC), which is theoretically predicted to have a robust quadratic dependence on the CA concentration even when the CA is compartmentalized. In this study, CA concentration estimation by means of MFC is shown to be more accurate than established methods based on relaxation rates in yeast cell suspensions.
Vishal Patil; Glyn Johnson; Jens H Jensen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  62     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2010-01-04     Revised Date:  2013-09-20    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1002-6     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York 10016-3295, USA.
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MeSH Terms
Contrast Media / pharmacokinetics*
Electromagnetic Fields
Gadolinium DTPA / diagnostic use,  pharmacokinetics*
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Magnetic Resonance Spectroscopy / methods*
Reproducibility of Results
Saccharomyces cerevisiae / cytology*,  metabolism*
Sensitivity and Specificity
Grant Support
R01 CA093992/CA/NCI NIH HHS; R01 CA111996/CA/NCI NIH HHS; R01CA093992/CA/NCI NIH HHS; R01CA111996/CA/NCI NIH HHS
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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