Document Detail


Robust growth hormone (GH) secretion in aged female rats co-administered GH-releasing hexapeptide (GHRP-6) and GH-releasing hormone (GHRH).
MedLine Citation:
PMID:  1943453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aging is associated with a blunted growth hormone (GH) secretory response to GH-releasing hormone (GHRH), in vivo. The objective of the present study was to assess the effects of aging on the GH secretory response to GH-releasing hexapeptide (GHRP-6), a synthetic GH secretagogue. GHRP-6 (30 micrograms/kg) was administered alone or in combination with GHRH (2 micrograms/kg) to anesthetized female Fischer 344 rats, 3 or 19 months of age. The peptides were co-administered to determine the effect of aging upon the potentiating effect of GHRP-6 on GHRH activity. The increase in plasma GH as a function of time following administration of GHRP-6 was lower (p less than 0.001) in old rats than in young rats; whereas the increase in plasma GH secretion as a function of time following co-administration of GHRP-6 and GHRH was higher (p less than 0.001) in old rats than in young rats (mean Cmax = 8539 +/- 790.6 micrograms/l vs. 2970 +/- 866 micrograms/l, respectively; p less than 0.01). Since pituitary GH concentrations in old rats were lower than in young rats (257.0 +/- 59.8 micrograms/mg wet wt. vs. 639.7 +/- 149.2 micrograms/mg wet wt., respectively; p less than 0.03), the results suggested that GH functional reserve in old female rats was not linked to pituitary GH concentration. The differential responses of old rats to individually administered and co-administered GHRP-6 are important because they demonstrate that robust and immediate GH secretion can occur in old rats that are appropriately stimulated. The data further suggest that the cellular processes subserving GH secretion are intact in old rats, and that age-related decrements in GH secretion result from inadequate stimulation, rather than to maladaptive changes in the mechanism of GH release.
Authors:
R F Walker; S W Yang; B B Bercu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  49     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1991  
Date Detail:
Created Date:  1991-12-13     Completed Date:  1991-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1499-504     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of South Florida College of Medicine, Tampa 33612.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Female
Growth Hormone / blood*
Growth Hormone-Releasing Hormone / pharmacology*
Oligopeptides / pharmacology*
Radioimmunoassay
Rats
Rats, Inbred F344
Chemical
Reg. No./Substance:
0/Oligopeptides; 87616-84-0/growth hormone releasing hexapeptide; 9002-72-6/Growth Hormone; 9034-39-3/Growth Hormone-Releasing Hormone

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