Document Detail

Robust control in bacterial regulatory circuits.
MedLine Citation:
PMID:  15063859     Owner:  NLM     Status:  MEDLINE    
Robust control refers to regulatory systems that are insensitive to perturbations to the intra- or extra-cellular environment. It is generally believed that most cell regulatory circuits should possess some degree of robustness. Examples of robust control and the underlying mechanisms for achieving this robustness are only beginning to be uncovered. Various forms of robustness are associated with circuits based on negative and/or positive feedback, bi-functional enzymes, protein oligomerization and discrete or continuous control.
Mark Goulian
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in microbiology     Volume:  7     ISSN:  1369-5274     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-06-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  198-202     Citation Subset:  IM    
Department of Physics and Institute for Medicine and Engineering, University of Pennsylvania, 209 S. 33rd Street, Philadelphia, PA 19104, USA.
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MeSH Terms
Bacteria / genetics*
Gene Expression Regulation, Bacterial / physiology*
Transcription, Genetic / physiology*

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