| Robust and Responsive Silk Ionomer Microcapsules. | |
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MedLine Citation:
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PMID: 22050007 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We demonstrate the assembly of extremely robust and pH-responsive thin shell LbL microcapsules from silk fibroin counterparts modified with poly(lysine) and poly(glutamic) acid which are based on biocompatible silk ionomer materials in contrast to usually exploited synthetic polyelectrolytes. The microcapsules are extremely stable in the unusually wide pH range from 1.5 to 12.0 and show remarkable degree of reversible swelling/deswelling response in dimensions as exposed to extreme acidic and basic conditions. These changes are accompanied by reversible changes in shell permeability which can be utilized for pH-controlled loading and unloading of large macromolecules. Finally, we confirmed that these shells can be utilized to encapsulate yeast cells with viability rate much higher than that for traditional synthetic polyelectrolytes. |
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Authors:
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Chunghong Ye; Olga Shchepelina; Rossella Calabrese; Irina Drachuck; David L Kaplan; Vladimir V Tsukruk |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-3 |
Journal Detail:
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Title: Biomacromolecules Volume: - ISSN: 1526-4602 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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