| Robust DNA Functionalized Core/Shell Quantum Dots with Fluorescent Emission Spanning from UV-Vis to Near IR and Compatible with DNA Directed Self-Assembly. | |
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MedLine Citation:
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PMID: 23036133 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The assembly and isolation of DNA oligonucleotide functionalized gold nanoparticles (AuNPs) has become a well-developed technology due to the strong bonding interactions be-tween gold and thiolated DNA. However, achieving DNA func-tionalized semiconductor quantum dots (QDs) that are robust enough to withstand precipitation at high temperature and ionic strength through simple 'attachment' of modified DNA on the QD surface remains a challenge. Here we report a method that facili-tates the synthesis of stable core/shell (1 to 20 monolayers) QD-DNA conjugates by 'embedding' the end part (5-10 nucleotides) of the phosphorothiolated oligonucleotides within the outer shell of the QDs. These reliable QD-DNA conjugates exhibit excellent chemical and photonic stability, colloidal stability over a wide pH range (4-12) and high salt (>100 mM Na+ or Mg2+) conditions, bright fluorescence emission with quantum yield up to 70%, and broad spectra tunability with emission ranging from ultraviolet to near infrared. |
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Authors:
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Zhengtao Deng; Anirban Samanta; Jeanette Nangreave; Hao Yan; Yan Liu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-5 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: - ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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