Document Detail


Robust DNA Functionalized Core/Shell Quantum Dots with Fluorescent Emission Spanning from UV-Vis to Near IR and Compatible with DNA Directed Self-Assembly.
MedLine Citation:
PMID:  23036133     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The assembly and isolation of DNA oligonucleotide functionalized gold nanoparticles (AuNPs) has become a well-developed technology due to the strong bonding interactions be-tween gold and thiolated DNA. However, achieving DNA func-tionalized semiconductor quantum dots (QDs) that are robust enough to withstand precipitation at high temperature and ionic strength through simple 'attachment' of modified DNA on the QD surface remains a challenge. Here we report a method that facili-tates the synthesis of stable core/shell (1 to 20 monolayers) QD-DNA conjugates by 'embedding' the end part (5-10 nucleotides) of the phosphorothiolated oligonucleotides within the outer shell of the QDs. These reliable QD-DNA conjugates exhibit excellent chemical and photonic stability, colloidal stability over a wide pH range (4-12) and high salt (>100 mM Na+ or Mg2+) conditions, bright fluorescence emission with quantum yield up to 70%, and broad spectra tunability with emission ranging from ultraviolet to near infrared.
Authors:
Zhengtao Deng; Anirban Samanta; Jeanette Nangreave; Hao Yan; Yan Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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