| On the road to combinations of targeted therapies: PPM1H phosphatase as a suppressor of trastuzumab resistance. | |
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MedLine Citation:
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PMID: 22586608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lee-Hoeflich and colleagues use RNA interference screening to identify the serine/threonine phosphatase PPM1H as an inhibitor of trastuzumab resistance in vitro. This finding extends the molecular portrait of trastuzumab-resistant cells and provides a rationale when searching for potential therapeutic targets among regulators of PPM1H and/or its substrates. |
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Authors:
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Nicola Aceto; Mohamed Bentires-Alj |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Cancer discovery Volume: 1 ISSN: 2159-8290 ISO Abbreviation: Cancer Discov Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2012-05-15 Completed Date: 2012-11-21 Revised Date: 2013-05-08 |
Medline Journal Info:
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Nlm Unique ID: 101561693 Medline TA: Cancer Discov Country: United States |
Other Details:
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Languages: eng Pagination: 285-6 Citation Subset: IM |
Copyright Information:
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©2011 AACR. |
Affiliation:
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Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. bentires@fmi.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal, Humanized
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pharmacology* Cyclin-Dependent Kinase Inhibitor p27 / genetics* Female Humans Phosphoprotein Phosphatases / genetics*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal, Humanized; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27; EC 3.1.3.16/PPM1H protein, human; EC 3.1.3.16/Phosphoprotein Phosphatases; P188ANX8CK/trastuzumab |
| Comments/Corrections | |
Comment On:
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Cancer Discov. 2011 Sep;1(4):326-37
[PMID:
22586611
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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