Document Detail


Ro 31-8220 inhibits release of interleukin-1 and interleukin-6 from mouse peritoneal macrophages induced by fibrin fibrinogen degradation products.
MedLine Citation:
PMID:  10678095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To study the effect of fibrin fibrinogen degradation products (FFDP) on release of interleukin-1 (IL-1) and interleukin-6 (IL-6) from mouse peritoneal macrophages, and the effect of a new selectively potent protein kinase C inhibitor Ro 31-8220 (Ro). METHODS: IL-1 and IL-6 activities were measured by thymocyte proliferation assay and B9 cell proliferation methyl thiazolyl tetrazolium (MTT) colorimetric method, respectively. RESULTS: Ro 0.01-1 mumol.L-1 obviously inhibited FFDP-induced release of IL-1 and IL-6 from mouse peritoneal macrophages. CONCLUSION: Ro exerted inhibitory effects on FFDP-induced release of IL-1 and IL-6 in vitro.
Authors:
B Zhou; J P Zhang; Z L Hu; Y X Tan; D H Qian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zhongguo yao li xue bao = Acta pharmacologica Sinica     Volume:  20     ISSN:  0253-9756     ISO Abbreviation:  Zhongguo Yao Li Xue Bao     Publication Date:  1999 May 
Date Detail:
Created Date:  2000-05-18     Completed Date:  2000-05-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8100330     Medline TA:  Zhongguo Yao Li Xue Bao     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  449-51     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai, China. zhoubin@ecmu.org.cn
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MeSH Terms
Descriptor/Qualifier:
Animals
Fibrin Fibrinogen Degradation Products / antagonists & inhibitors
Indoles / pharmacology*
Interleukin-1 / metabolism*
Interleukin-6 / metabolism*
Macrophages, Peritoneal / metabolism*
Mice
Mice, Inbred ICR
Protein Kinase C / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Indoles; 0/Interleukin-1; 0/Interleukin-6; 125314-64-9/Ro 31-8220; EC 2.7.11.13/Protein Kinase C

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