| Ro 15-1788 and beta-CCE selectively eliminate diazepam-induced feeding in the rabbit. | |
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MedLine Citation:
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PMID: 6330765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Food intake was monitored in three female and one male adult rabbits following the administration of three drugs known to result in feeding increases in other species. The drugs, diazepam (1.0 mg/kg), cyproheptadine (0.03 mg/kg) and chlorpromazine (1.0 mg/kg) all produced large increases in food intake; of these, only the effect of diazepam, a benzodiazepine, was reversed by doses of the benzodiazepine antagonists Ro 15-1788 (0.3 mg/kg) and Ethyl beta-carboxylate (beta-CCE) (1.0 mg/kg) which, when given alone, did not affect feeding. The results support evidence suggesting that Ro 15-1788 and beta-CCE are specific antagonists of the benzodiazepine receptor and of their effects on a wide range of behaviors. |
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Authors:
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R S Mansbach; J A Stanley; J E Barrett |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 20 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-08-07 Completed Date: 1984-08-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 763-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzodiazepinones / pharmacology* Carbolines / pharmacology* Chlorpromazine / pharmacology Cyproheptadine / pharmacology Diazepam / antagonists & inhibitors*, pharmacology Eating / drug effects* Flumazenil Indoles / pharmacology* Rabbits Receptors, Cell Surface / drug effects Receptors, GABA-A Water Deprivation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DA-02873/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzodiazepinones; 0/Carbolines; 0/Indoles; 0/Receptors, Cell Surface; 0/Receptors, GABA-A; 129-03-3/Cyproheptadine; 439-14-5/Diazepam; 50-53-3/Chlorpromazine; 74214-62-3/beta-carboline-3-carboxylic acid ethyl ester; 78755-81-4/Flumazenil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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