Document Detail


Ro 15-1788 and beta-CCE selectively eliminate diazepam-induced feeding in the rabbit.
MedLine Citation:
PMID:  6330765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food intake was monitored in three female and one male adult rabbits following the administration of three drugs known to result in feeding increases in other species. The drugs, diazepam (1.0 mg/kg), cyproheptadine (0.03 mg/kg) and chlorpromazine (1.0 mg/kg) all produced large increases in food intake; of these, only the effect of diazepam, a benzodiazepine, was reversed by doses of the benzodiazepine antagonists Ro 15-1788 (0.3 mg/kg) and Ethyl beta-carboxylate (beta-CCE) (1.0 mg/kg) which, when given alone, did not affect feeding. The results support evidence suggesting that Ro 15-1788 and beta-CCE are specific antagonists of the benzodiazepine receptor and of their effects on a wide range of behaviors.
Authors:
R S Mansbach; J A Stanley; J E Barrett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  20     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-08-07     Completed Date:  1984-08-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  763-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzodiazepinones / pharmacology*
Carbolines / pharmacology*
Chlorpromazine / pharmacology
Cyproheptadine / pharmacology
Diazepam / antagonists & inhibitors*,  pharmacology
Eating / drug effects*
Flumazenil
Indoles / pharmacology*
Rabbits
Receptors, Cell Surface / drug effects
Receptors, GABA-A
Water Deprivation / physiology
Grant Support
ID/Acronym/Agency:
DA-02873/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Benzodiazepinones; 0/Carbolines; 0/Indoles; 0/Receptors, Cell Surface; 0/Receptors, GABA-A; 129-03-3/Cyproheptadine; 439-14-5/Diazepam; 50-53-3/Chlorpromazine; 74214-62-3/beta-carboline-3-carboxylic acid ethyl ester; 78755-81-4/Flumazenil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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