Document Detail

Rivaroxaban for the treatment of venous thromboembolism. A "real-life" perspective in 103 patients.
MedLine Citation:
PMID:  25034320     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Randomized clinical trials have demonstrated non-inferiority of rivaroxaban compared with vitamin K antagonists (VKAs) in the treatment of venous thromboembolism (VTE). Our objective was to analyze in real life, tolerance, recurrence, bleeding and adverse events of rivaroxaban in patients with acute symptomatic VTE.
MATERIAL AND METHODS: Open follow-up study of a cohort of patients aged 18 and over diagnosed with deep vein thrombosis (DVT) and/or pulmonary embolism (PE) treated with rivaroxaban from December 2011 to January 2014.
RESULTS: The total number of patients treated with rivaroxaban was 103. The mean age was 58+/-17years. The most frequent co-morbidities were: hypertension (30.0%), dyslipidemia (23.3%) and respiratory disease (25.2%). The type of thromboembolic event treated was: DVT (64.1%), PE (18.4%), DVT+PE (17.5%). Of the rivaroxaban-treated patients, 30% did so from the initial anticoagulant therapy and the other 70% in long-term or extended anticoagulant therapy. The median time of treatment with rivaroxaban was 5months. There was one recurrence and no deaths occurred. Six patients had bleeding, one of which was severe.
CONCLUSIONS: Rivaroxaban provides a therapeutic alternative in a group of patients with VTE with advantages over VKAs, because of the convenience in dosing, lack of requirements for periodic monitoring and limited interaction with other drugs.
Luis Jara-Palomares; Raquel Sanchez-Oro-Gomez; Teresa Elias-Hernandez; Raquel Morillo-Guerrero; Marta Ferrer-Galvan; Maria Isabel Asensio-Cruz; Emilia Barrot-Cortes; Remedios Otero-Candelera
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-5
Journal Detail:
Title:  Thrombosis research     Volume:  -     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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