| Rivaroxaban: a review of its use for the prevention of venous thromboembolism after total hip or knee replacement surgery. | |
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MedLine Citation:
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PMID: 19719335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rivaroxaban (Xarelto), an oral oxazolidinone-based anticoagulant, is a potent, selective direct inhibitor of factor Xa that is used in the prevention of venous thromboembolism (VTE) in adult patients after total hip replacement (THR) or total knee replacement (TKR) surgery. In four large, clinical trials, oral rivaroxaban was more effective than subcutaneous enoxaparin in preventing postoperative VTE in patients undergoing THR or TKR surgery. Notably, the superior efficacy of rivaroxaban was achieved with a low but not significant increase in the incidence of major bleeding episodes. In addition, preliminary pharmacoeconomic analyses in several countries indicate that rivaroxaban is a cost-effective treatment strategy versus enoxaparin. Although the position of rivaroxaban relative to other therapies remains to be fully determined, it is an effective emerging option for the prevention of VTE following THR and TKR. |
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Authors:
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Sean T Duggan; Lesley J Scott; Greg L Plosker |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drugs Volume: 69 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 2009 |
Date Detail:
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Created Date: 2009-09-01 Completed Date: 2010-02-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: New Zealand |
Other Details:
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Languages: eng Pagination: 1829-51 Citation Subset: IM |
Affiliation:
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Wolters Kluwer Health, Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore 0754, Auckland, New Zealand. demail@adis.co.nz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticoagulants / adverse effects, economics, pharmacology, therapeutic use Arthroplasty, Replacement, Hip / adverse effects* Arthroplasty, Replacement, Knee / adverse effects* Clinical Trials as Topic Humans Morpholines / adverse effects, economics, pharmacology*, therapeutic use Thiophenes / adverse effects, economics, pharmacology*, therapeutic use Venous Thromboembolism / etiology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Morpholines; 0/Thiophenes; 0/rivaroxaban |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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