Document Detail

Rituximab treatment of pulmonary arterial hypertension associated with systemic lupus erythematosus: a case report.
MedLine Citation:
PMID:  18625655     Owner:  NLM     Status:  MEDLINE    
Pulmonary hypertension is a common but underdiagnosed complication of systemic lupus erythematosus, which can be associated with significant morbidity and early mortality. Although often associated with anti-phospholipid antibodies, the etiology remains poorly understood. In case reports and small open trials, the anti-CD20, B-cell targeted therapeutic antibody, rituximab, has been reported to provide benefits for systemic lupus erythematosus patients with glomerulonephritis, anti-phospholipid antibody syndrome, vasculitis, arthritis, and refractory skin disease. However, the outcome of rituximab treatment of pulmonary arterial hypertension associated with systemic lupus erythematosus has not been described. We, therefore, present a case of a young systemic lupus erythematosus patient with early onset of pulmonary arterial hypertension during the disease course, refractory to multiple treatment modalities, who had significant improvement with rituximab therapy.
S Hennigan; R N Channick; G J Silverman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Lupus     Volume:  17     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-15     Completed Date:  2008-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  754-6     Citation Subset:  IM    
Department of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
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MeSH Terms
Antibodies, Monoclonal / therapeutic use*
Hypertension, Pulmonary / drug therapy*,  etiology
Lupus Erythematosus, Systemic / complications*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/rituximab

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