| Rituximab treatment of pulmonary arterial hypertension associated with systemic lupus erythematosus: a case report. | |
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MedLine Citation:
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PMID: 18625655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary hypertension is a common but underdiagnosed complication of systemic lupus erythematosus, which can be associated with significant morbidity and early mortality. Although often associated with anti-phospholipid antibodies, the etiology remains poorly understood. In case reports and small open trials, the anti-CD20, B-cell targeted therapeutic antibody, rituximab, has been reported to provide benefits for systemic lupus erythematosus patients with glomerulonephritis, anti-phospholipid antibody syndrome, vasculitis, arthritis, and refractory skin disease. However, the outcome of rituximab treatment of pulmonary arterial hypertension associated with systemic lupus erythematosus has not been described. We, therefore, present a case of a young systemic lupus erythematosus patient with early onset of pulmonary arterial hypertension during the disease course, refractory to multiple treatment modalities, who had significant improvement with rituximab therapy. |
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Authors:
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S Hennigan; R N Channick; G J Silverman |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Lupus Volume: 17 ISSN: 0961-2033 ISO Abbreviation: Lupus Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-15 Completed Date: 2008-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204265 Medline TA: Lupus Country: England |
Other Details:
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Languages: eng Pagination: 754-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Monoclonal / therapeutic use* Female Humans Hypertension, Pulmonary / drug therapy*, etiology Lupus Erythematosus, Systemic / complications* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/rituximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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