| Rituximab therapy in severe juvenile pemphigus vulgaris. | |
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MedLine Citation:
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PMID: 18038698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Juvenile pemphigus vulgaris (PV) is a rare and often misdiagnosed condition. Although PV frequently is severe in children, a substantial portion of the morbidity and mortality associated with juvenile PV has been attributed to treatment. This report demonstrates the efficacy of rituximab therapy in juvenile PV. We report 2 cases and review the literature. Rituximab treatment was effective in helping to control 2 recalcitrant cases of juvenile PV without inducing the adverse effects associated with other adjuvant therapies. Rituximab should be considered when treating resistant cases of PV in pediatric populations to avoid the long-term side effects of other immunosuppressive treatments. |
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Authors:
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Adam J Mamelak; Mark P Eid; Bernard A Cohen; Grant J Anhalt |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cutis; cutaneous medicine for the practitioner Volume: 80 ISSN: 0011-4162 ISO Abbreviation: Cutis Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-11-27 Completed Date: 2008-02-27 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006440 Medline TA: Cutis Country: United States |
Other Details:
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Languages: eng Pagination: 335-40 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Johns Hopkins University, Baltimore, MD 21287, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antibodies, Monoclonal / therapeutic use* Female Humans Immunologic Factors / therapeutic use* Pemphigus / drug therapy*, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Immunologic Factors; 0/rituximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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