Document Detail


Rituximab therapy in nephrotic syndrome due to AH amyloidosis.
MedLine Citation:
PMID:  19590993     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a patient with AH amyloidosis associated with lymphoplasmacytic leukemia that has remained in a stable state with a nephrotic syndrome for 17 months since the commencement of cyclic rituximab therapy aimed at suppression of pathogenetic gamma heavy chains. Free light chains in serum and CD20-positive cells in peripheral blood were useful as hematological markers in the patient. Rituximab might be a potent therapeutic option for AH amyloidosis associated with a B-cell lymphoproliferative disorder.
Authors:
Nagaaki Katoh; Masayuki Matsuda; Daigo Miyazaki; Takahisa Gono; Masahide Yazaki; Shu-Ichi Ikeda
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Publication Detail:
Type:  Case Reports; Letter; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis     Volume:  16     ISSN:  1744-2818     ISO Abbreviation:  Amyloid     Publication Date:  2009  
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-09-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433802     Medline TA:  Amyloid     Country:  England    
Other Details:
Languages:  eng     Pagination:  178-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amyloidosis / complications*,  drug therapy*,  etiology
Antibodies / genetics,  immunology
Antibodies, Monoclonal / therapeutic use*
Antirheumatic Agents / therapeutic use*
Female
Humans
Middle Aged
Neoplasms, Plasma Cell / complications,  drug therapy
Nephrotic Syndrome* / drug therapy,  etiology
Chemical
Reg. No./Substance:
0/Antibodies; 0/Antibodies, Monoclonal; 0/Antirheumatic Agents; 0/rituximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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