Document Detail


Rituximab in refractory and non-refractory myasthenia: A retrospective multicenter study.
MedLine Citation:
PMID:  22941747     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Few data are available about the effect of rituximab (RTX) on refractory (RM) and non-refractory (NRM) myasthenia. METHODS: This retrospective multicenter study involved 13 RM and 7 NRM patients treated with sequential RTX infusions over 2 years, on average. RTX was used as a substitute for corticosteroids in NRM patients. Disability was assessed using the annualized relapse rate (ARR) and Myasthenia Gravis Foundation of America (MGFA) scores. RESULTS: RTX induction decreased the ARR from 2.1 to 0.3 (P < 0.001), and lowered MGFA scores from 5-3b to 4b-0 in RM patients, and from 1.9 to 0.1 (P < 0.001) and 4b-2b to 3b-0 in NRM patients. No side effects were reported in either group, except for 1 case of spondylodiscitis 1 year after the last RTX infusion. Within a year after RTX induction, complete corticosteroid withdrawal was obtained in 7 RM and 4 NRM patients. CONCLUSIONS: RTX is efficacious and well-tolerated. Its use allows for dose reduction or withdrawal of corticosteroids. Muscle Nerve, 2012.
Authors:
Nicolas Collongues; Olivier Casez; Arnaud Lacour; Christine Tranchant; Patrick Vermersch; Jérôme de Seze; Christine Lebrun
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-14
Journal Detail:
Title:  Muscle & nerve     Volume:  -     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-9-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Neurology, University of Strasbourg, University Hospital of Hautepierre, 1 Avenue Molière, 67000 Strasbourg, France. nicolas.collongues@chru.strasbourg.fr.
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