Document Detail

Rituximab in Lymphomatoid Granulomatosis.
MedLine Citation:
PMID:  23337550     Owner:  NLM     Status:  Publisher    
BACKGROUND:: Lymphomatoid granulomatosis (LG) is an Epstein-Barr virus-associated, multisystemic disease that combines a granulomatous inflammatory process with lymphoproliferative potential. It is a rare disorder with a variable clinical presentation ranging from an indolent process to an aggressive B-cell lymphoma. Outcome is unpredictable, and a standard treatment has not yet been established. Cases treated with rituximab, an anti-CD20 monoclonal antibody, have been reported with variable results. OBSERVATION:: We report on 2 children with LG treated with rituximab and review the literature. The first patient had good response but the second did not. CONCLUSIONS:: Rituximab is a treatment option for LG.
Carmen Hernández-Marqués; Alvaro Lassaletta; Antonio Torrelo; Miguel Angel López-Pino; Javier Alvarez-Coca; Inmaculada De Prada; Angela Hernández-Martín; Luis Madero
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  -     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of *Pediatric Hematology-Oncology †Dermatology ‡Radiology §Paediatrics ∥Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
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