| Rituximab-cyclophosphamide-dexamethasone combination in management of autoimmune cytopenias associated with chronic lymphocytic leukemia. | |
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MedLine Citation:
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PMID: 21699387 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract We report our experience on rituximab-cyclophosphamide-dexamethasone (RCD) combination therapy for the treatment of autoimmune disorders in 48 patients with chronic lymphocytic leukemia (CLL). The diagnosis of autoimmune disease (AID) was autoimmune hemolytic anemia (AIHA) in 26 (54%), autoimmune thrombocytopenic purpura (AITP) in nine (18.8%), Evans syndrome in eight (16.7%), and pure red cell anemia (PRCA) in five patients (10.5%). CLL was considered progressive in 40% of subjects upon AID diagnosis. Overall, an 89.5% response rate was obtained with this combination, irrespective of the AID type. Relapse occurred in 19 patients (39.6%). The median duration of autoimmunity was 24 months, but the duration of response of autoimmunity (DR-AI) was higher for patients presenting with: (1) AID early during the CLL course (<3 years), or (2) both and pure red cell aplasia (PRCA) in five patients (10.5%) and AIHA. |
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Authors:
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Anne-Sophie Michallet; Julien Rossignol; Bruno Cazin; Loic Ysebaert |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 52 ISSN: 1029-2403 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: England |
Other Details:
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Languages: eng Pagination: 1401-3 Citation Subset: IM |
Affiliation:
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Hospices Civils de Lyon, Department of Hematology, Lyon-Sud University Hospital, Pierre-Bénite, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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