Document Detail

Ritonavir for preventing perinatal HIV transmission.
MedLine Citation:
PMID:  11366688     Owner:  NLM     Status:  MEDLINE    
A Thai study on short-term Ritonavir treatment to interrupt perinatal HIV transmission was presented at 6th CROI by S. Limpongsanurak. The safety, tolerability, and efficacy of Ritonavir were examined in a phase IV open-label study involving 86 pregnant women. Ritonavir was given two weeks before their due dates, with dosages gradually increased up to 600 mg twice daily. Breast-feeding was not permitted. Seventy-four mothers completed the study, and perinatal HIV transmission rate was 9.46 percent. In comparison, the rate of perinatal transmission without treatment in the U.S. is 25 percent. Researchers credit Ritonavir with reducing maternal viral load and the rate of perinatal HIV transmission.
L Hanna
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Publication Detail:
Type:  Newspaper Article    
Journal Detail:
Title:  BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation     Volume:  12     ISSN:  1058-708X     ISO Abbreviation:  BETA     Publication Date:  1999 Apr 
Date Detail:
Created Date:  2000-05-31     Completed Date:  2000-05-31     Revised Date:  2014-08-25    
Medline Journal Info:
Nlm Unique ID:  9113964     Medline TA:  BETA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  20     Citation Subset:  X    
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MeSH Terms
Clinical Trials, Phase IV as Topic
HIV Infections / transmission*
HIV Protease Inhibitors / therapeutic use*
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Ritonavir / therapeutic use*
Viral Load
Reg. No./Substance:
0/HIV Protease Inhibitors; O3J8G9O825/Ritonavir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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