Document Detail


Ritonavir-induced acute kidney injury: kidney biopsy findings and review of literature.
MedLine Citation:
PMID:  21269596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ritonavir therapy is not generally considered nephrotoxic. We report a case of acute kidney injury secondary to ritonavir, with kidney biopsy demonstrating extensive acute tubular injury. This is the first report of a kidney biopsy and pathology in acute kidney injury associated with ritonavir. A review of published medical literature on the topic is also presented.
Authors:
T Shafi; M J Choi; L C Racusen; L A Spacek; C Berry; M Atta; D M Fine
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical nephrology     Volume:  75 Suppl 1     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-28     Completed Date:  2011-04-06     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  60-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Kidney Injury / chemically induced*,  pathology
Antiretroviral Therapy, Highly Active
Biological Markers / blood
Biopsy
Creatinine / blood
Drug Substitution
HIV Infections / drug therapy*
HIV Protease Inhibitors / adverse effects*
Humans
Kidney / drug effects*,  pathology
Kidney Tubules / drug effects,  pathology
Male
Middle Aged
Ritonavir / adverse effects*
Time Factors
Grant Support
ID/Acronym/Agency:
5T32-DK-007732-12/DK/NIDDK NIH HHS; K23 DK083514/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/HIV Protease Inhibitors; AYI8EX34EU/Creatinine; O3J8G9O825/Ritonavir
Comments/Corrections

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