Document Detail


Risperidone and breast-feeding.
MedLine Citation:
PMID:  15728443     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present the case of a breast-feeding woman with acute psychotic symptoms after delivery, which were treated with the antipsychotic agent risperidone. Serum levels of risperidone and 9-hydroxyrisperidone could be detected in both the mother and her infant. Drug-levels in breast milk were ten-fold lower compared to maternal serum. The patient responded well to antipsychotic treatment. Her infant did not display any adverse effects and psychomotor development was normal. In this case, risperidone was a safe treatment option for the breast-feeding mother and her infant. We also provide a brief overview of the clinically relevant data concerning antipsychotics and breast-feeding.
Authors:
W Aichhorn; C Stuppaeck; A B Whitworth
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  19     ISSN:  0269-8811     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-24     Completed Date:  2005-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  211-3     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Innsbruck, Innsbruck, Austria. wolfgang.aichhorn@uibk.ac.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Antipsychotic Agents / pharmacokinetics*,  therapeutic use
Breast Feeding*
Dose-Response Relationship, Drug
Female
Humans
Infant, Newborn
Isoxazoles / blood,  metabolism
Milk, Human / metabolism
Postpartum Period / psychology*
Psychotic Disorders / drug therapy*,  metabolism*
Pyrimidines / blood,  metabolism
Risperidone / pharmacokinetics*,  therapeutic use
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Isoxazoles; 0/Pyrimidines; 106266-06-2/Risperidone; 144598-75-4/9-hydroxy-risperidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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