Document Detail

Risperidone augmentation of serotonin reuptake inhibitors in obsessive-compulsive and related disorders.
MedLine Citation:
PMID:  9108814     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: While serotonin is the neurotransmitter most commonly implicated in obsessive-compulsive and related disorders, there is also evidence for dopaminergic mediation of these conditions. Indeed, augmentation of serotonin reuptake inhibitors with the atypical neuroleptic risperidone has been suggested to be useful in obsessive-compulsive disorder (OCD). METHOD: Charts of all patients treated in our OCD clinic with the combination of a serotonin reuptake inhibitor and risperidone were reviewed. Demographic details of patients and clinical response to this pharmacotherapeutic strategy were tabulated. RESULTS: A series of patients with OCD (N = 8), trichotillomania (N = 5), and Tourette's syndrome (N = 3) who were refractory to treatment with serotonin reuptake inhibitors had received risperidone augmentation. In a number of cases, this strategy proved clinically effective. However, a minority of patients experienced significant adverse effects. CONCLUSION: Patients with OCD and related disorders are not infrequently refractory to treatment with serotonin reuptake inhibitors. Controlled trials of risperidone augmentation in such patients seem warranted. In particular, it is necessary to determine an appropriate dose range to minimize adverse effects.
D J Stein; C Bouwer; S Hawkridge; R A Emsley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  58     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-28     Completed Date:  1997-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  IM    
Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa.
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MeSH Terms
Drug Therapy, Combination
Hospital Records
Middle Aged
Obsessive-Compulsive Disorder / drug therapy*,  psychology
Psychiatric Status Rating Scales
Risperidone / therapeutic use*
Serotonin Uptake Inhibitors / therapeutic use*
Tourette Syndrome / drug therapy*,  psychology
Trichotillomania / drug therapy*,  psychology
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 106266-06-2/Risperidone
Comment In:
J Clin Psychiatry. 1998 Mar;59(3):134   [PMID:  9541161 ]

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