Document Detail

Risks for premature rupture of amniotic membranes.
MedLine Citation:
PMID:  8359967     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to test the hypothesis that diverse risk variables including infections during the index pregnancy independently increase the risk of preterm premature rupture of amniotic membranes (PROM) and preterm delivery without PROM. A case-control design was used to study women 15-45 years old who had preterm PROM, full-term PROM or preterm without PROM and were singly matched by age race and parity to controls who delivered full-term infants. The odds for preterm PROM was 6.0 times that of controls among women with intra-amniotic infection, 3.7 times among those with urinary tract and 7.6 times among women with gonorrhoea infections after controlling for the effects of exposure to cigarette smoke, having previous preterm and full-term PROM deliveries and antepartum bleeding that independently increased the odds. The odds for preterm births without PROM was 4.8 times that of controls among women with a previous preterm PROM birth, was significantly increased among those exposed to cigarette smoke or having antepartum bleeding, but not among those exposed to chlamydia infection. Even after adjusting for concomitant risk factors, women with preterm PROM births were more likely than their matched controls to have had infections.
E E Ekwo; C A Gosselink; R Woolson; A Moawad
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of epidemiology     Volume:  22     ISSN:  0300-5771     ISO Abbreviation:  Int J Epidemiol     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-09-30     Completed Date:  1993-09-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  495-503     Citation Subset:  IM    
University of Chicago Pritzker School of Medicine/La Rabida Children's Hospital, IL 60649.
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MeSH Terms
Bacterial Infections / complications*
Case-Control Studies
Chlamydia Infections / complications
Educational Status
Fetal Membranes, Premature Rupture / etiology*
Marital Status
Middle Aged
Obstetric Labor, Premature
Pregnancy Complications, Infectious*
Risk Factors
Tobacco Smoke Pollution / adverse effects
Grant Support
Reg. No./Substance:
0/Tobacco Smoke Pollution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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