| Risks and benefits of attaining HbA(1c) goals: examining the evidence. | |
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MedLine Citation:
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PMID: 20644204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Type 2 diabetes mellitus (T2DM) is associated with an increased risk of microvascular and macrovascular complications. To manage T2DM, the American Diabetes Association recommends lowering glycated hemoglobin levels to less than 7%, but even lower goals may be possible in patients with low risk of hypoglycemia. Although many studies have demonstrated that aggressive glycemic control has a clear benefit in the reduction of microvascular complications, more data are needed to further characterize the effect on macrovascular complications. Furthermore, researchers must consider the evidence of a "legacy effect," in which benefits do not become evident until years later. The risks of aggressive glycemic control, such as hypoglycemia and weight gain, must be weighed against the benefits in each individual patient. |
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Authors:
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Jay H Shubrook; Jay Shubrook |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Journal of the American Osteopathic Association Volume: 110 ISSN: 1945-1997 ISO Abbreviation: J Am Osteopath Assoc Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2011-03-07 Revised Date: 2011-03-15 |
Medline Journal Info:
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Nlm Unique ID: 7503065 Medline TA: J Am Osteopath Assoc Country: United States |
Other Details:
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Languages: eng Pagination: eS7-12 Citation Subset: IM |
Affiliation:
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Clinical Research, Ohio University College of Osteopathic Medicine, W Green Parks Hall, Suite 115, Athens, OH 45701, USA. shubrook@ohio.edu. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Blood Glucose / analysis* Diabetes Complications / prevention & control Diabetes Mellitus, Type 2 / physiopathology, prevention & control* Glycemic Index Hemoglobin A, Glycosylated / analysis* Humans Hypoglycemic Agents / therapeutic use Metformin / therapeutic use Practice Guidelines as Topic Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 657-24-9/Metformin |
| Comments/Corrections | |
Erratum In:
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J Am Osteopath Assoc. 2010 Oct;110(10):572 Note: Shubrook, Jay [corrected to Shubrook, Jay H Jr] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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