Document Detail


Risks of antibiotic residues in milk following intramammary and intramuscular treatments in dairy sheep.
MedLine Citation:
PMID:  19286006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Very few drugs on the market are approved for use in lactating ewes. Veterinarians in the European Union are allowed to prescribe drugs in an off-label manner but are then obligated to assure that residues do not enter the food chain. In case of mastitis treatment in dairy ewes antibiotic preparations designed and authorized for the bovine mammary gland are usually used. Due to inter-species differences, available bovine data cannot be accurately extrapolated for use in the dairy ewe. The objective of the study was therefore to determine appropriate withdrawal periods for ewe's milk following mastitis treatment with two commercial lactating cow products. For the detection of all components standard agar plate diffusion techniques were used. Regardless of the therapy regime and the product used, residues of antibiotics in milk were detected up to 192h after the last infusion. These results indicate that the required withholding periods for ewe's milk are considerably longer than recommended on the label for bovine milk.
Authors:
A Pengov; A Kirbis
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Publication Detail:
Type:  Journal Article     Date:  2008-09-16
Journal Detail:
Title:  Analytica chimica acta     Volume:  637     ISSN:  1873-4324     ISO Abbreviation:  Anal. Chim. Acta     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-16     Completed Date:  2009-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370534     Medline TA:  Anal Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  13-7     Citation Subset:  IM    
Affiliation:
Institute for Microbiology, Veterinary Faculty of Ljubljana, Gerbiceva 60, 1000 Ljubljana, Slovenia.
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MeSH Terms
Descriptor/Qualifier:
Amoxicillin / administration & dosage,  analysis
Animals
Anti-Bacterial Agents / administration & dosage,  analysis*
Anti-Infective Agents, Local / administration & dosage,  analysis*
Disk Diffusion Antimicrobial Tests
Drug Residues / analysis*
Female
Injections, Intramuscular
Lactation
Mastitis / drug therapy,  veterinary*
Milk / chemistry*
Penicillins / administration & dosage,  analysis
Pregnancy
Sheep
Sheep Diseases / drug therapy*
Time Factors
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents, Local; 0/Penicillins; 26787-78-0/Amoxicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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