| Risk stratification and prognosis of acute cardiac events in hospitalized adults with community-acquired pneumonia. | |
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MedLine Citation:
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PMID: 22981899 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the risk factors and the prognosis of acute cardiac events in patients with community-acquired pneumonia (CAP). METHODS: Observational analysis of a prospective cohort of hospitalized adults with CAP (1995-2010). A logistic regression analysis was performed to identify predictors for acute cardiac events and mortality. RESULTS: Of 3921 patients with CAP, 315 (8%) had one or more acute cardiac events during hospitalization (199 new-onset or worsening cardiac arrhythmias, 118 new-onset or worsening congestive heart failure and/or 30 myocardial infarction). In the multivariate analysis, factors associated with these events were age >65 years, chronic heart disease, chronic kidney disease, tachycardia, septic shock, multilobar pneumonia, hypoalbuminemia, and pneumococcal pneumonia. A rule based on these variables had an area under ROC curve of 0.73 (95% CI 0.70-0.76) to predict acute cardiac events. These complications occurred in 2.8% of patients classified in the low-risk (≤3 points), 9.7% in the intermediate-risk (4-5 points) and 21.2% in the high-risk (≥6 points) groups (P < .001). The overall case fatality rate was higher in patients who had acute cardiac events (19.4% vs. 6.4%; P < .001). CONCLUSION: Acute cardiac events occur frequently during hospitalization for CAP and are associated with poor prognosis. A simple rule based on demographic and clinical features may help identify patients at higher risk of these complications. |
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Authors:
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Diego Viasus; Carolina Garcia-Vidal; Frederic Manresa; Jordi Dorca; Francesc Gudiol; Jordi Carratalà |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-11 |
Journal Detail:
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Title: The Journal of infection Volume: - ISSN: 1532-2742 ISO Abbreviation: J. Infect. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7908424 Medline TA: J Infect Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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Department of Infectious Diseases, Hospital Universitari de Bellvitge - IDIBELL, Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain. Electronic address: dfviasusp@unal.edu.co. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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