Document Detail

Risk of significant coronary artery disease as determined by CT measurement of the distribution of abdominal adipose tissue.
MedLine Citation:
PMID:  11884776     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this work was to determine if CT measurement of the distribution of abdominal adipose tissue is reproducible between observers and is associated with patient risk of significant coronary artery disease. METHOD: We compared 11 male patients having abdominal CT who had a history of significant coronary artery disease and 9 male patients having abdominal CT without a history of coronary artery disease. Two observers, at the level of the umbilicus, independently measured the ratio of visceral adipose tissue (VAT) to total abdominal adipose tissue (TAT). VAT is equal to the sum total of intraperitoneal and retroperitoneal adipose tissue. TAT equals the sum total of visceral and subcutaneous adipose tissue. Measurements were made using a standard software package. RESULTS: The mean ratio of VAT to TAT was significantly different (p < 0.05) between patients with a history of coronary artery disease (mean = 0.51, SD = 0.10, range = 0.38-0.69) and without a history of coronary artery disease (mean = 0.40, SD = 0.12, range = 0.23-0.51). Agreement in measurements between observers was excellent (mean difference = 0.01, range = 0.00-0.03, intraclass correlation = 0.99). CONCLUSION: The measurement of the VAT/TAT ratio is highly reproducible between observers, and a high ratio is associated with patient risk of significant coronary artery disease.
Ahmet T Tirkes; Ronald H Gottlieb; Susan L Voci; David L Waldman; Jeffrey Masetta; David L Conover
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  26     ISSN:  0363-8715     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-03-08     Completed Date:  2002-04-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-5     Citation Subset:  IM    
Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
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MeSH Terms
Adipose Tissue*
Body Composition*
Coronary Artery Disease / etiology*
Middle Aged
Obesity / complications*
Observer Variation
Predictive Value of Tests
Reproducibility of Results
Risk Assessment
Tomography, X-Ray Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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