Document Detail

Risk of severe allergic reactions from the use of potassium iodide for radiation emergencies.
MedLine Citation:
PMID:  15577843     Owner:  NLM     Status:  MEDLINE    
Potassium iodide (KI) may be prescribed for widespread use in the event of a radiation emergency to prevent the uptake of radioactive iodide by the thyroid gland. The available literature was reviewed and expert opinion sought among members of the Adverse Reactions to Foods and the Adverse Reactions to Drugs and Biologicals Committees of the Academy to assemble evidenced-based conclusions regarding the risks of an allergic reaction to this therapy. This article describes the information leading to the following conclusions: (1) anaphylactoid reactions to radiocontrast media should not be considered evidence of KI allergy, (2) allergic contact dermatitis from iodine-containing antibacterial preparations should not be considered evidence of IgE antibody-mediated KI allergy or sensitivity, (3) IgE antibody-mediated allergy to seafood should not be considered evidence of KI allergy or sensitivity, and (4) physicians should ensure that persons are not allergic to inactive ingredients or components of the KI formulation prescribed.
Scott H Sicherer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  114     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-03     Completed Date:  2005-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1395-7     Citation Subset:  AIM; IM    
Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA.
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MeSH Terms
Contrast Media / adverse effects
Drug Hypersensitivity / etiology*
Immunoglobulin E / immunology
Iodine Radioisotopes / metabolism
Potassium Iodide / adverse effects*
Thyroid Gland / metabolism,  radiation effects
Reg. No./Substance:
0/Contrast Media; 0/Iodine Radioisotopes; 37341-29-0/Immunoglobulin E; 7681-11-0/Potassium Iodide

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