| Risk-reducing surgery for ovarian cancer: outcomes in 300 surgeries suggest a low peritoneal primary risk. | |
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MedLine Citation:
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PMID: 19367322 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Risk-reducing salpingo-oophorectomy is currently advocated for the reduction of both breast and ovarian cancer risk in BRCA1/2 carriers, but residual risk of peritoneal primary cancer remains a concern. A sequential series of women attending a single institution for ovarian risk management underwent either risk-reducing surgery or screening. A person-years at risk analysis was used to compare observed versus expected cancers. In total, 300 women underwent risk-reducing salpingo-oophorectomy, including 160 BRCA1/2 mutation carriers. Three occult ovarian cancers were detected at surgery. There have been 2400.4 years of follow-up and 15.79 expected cancers. No peritoneal cancers have occurred. Amongst 503 women controls with 3444.3 years of follow-up, 15.93 ovarian cancers were expected and 17 were found. There were six ovarian cancer-related deaths in the control group compared with one in the surgery group. Risk-reducing salpingo-oophorectomy in a single institution has so far avoided peritoneal cancer incidence. |
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Authors:
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D Gareth R Evans; Richard Clayton; Paul Donnai; Andrew Shenton; Fiona Lalloo |
Publication Detail:
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Type: Journal Article Date: 2009-04-15 |
Journal Detail:
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Title: European journal of human genetics : EJHG Volume: 17 ISSN: 1476-5438 ISO Abbreviation: Eur. J. Hum. Genet. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-22 Completed Date: 2010-01-12 Revised Date: 2010-12-17 |
Medline Journal Info:
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Nlm Unique ID: 9302235 Medline TA: Eur J Hum Genet Country: England |
Other Details:
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Languages: eng Pagination: 1381-5 Citation Subset: IM |
Affiliation:
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University of Manchester and Central Manchester and Manchester Children's University Hospitals NHS Trust, St Mary's Hospital, UK. Gareth.evans@cmmc.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Fallopian Tubes
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surgery* Female Follow-Up Studies Genes, BRCA1 Genetic Predisposition to Disease Heterozygote Humans Mutation Ovarian Neoplasms / genetics, prevention & control* Ovariectomy* Peritoneal Neoplasms / epidemiology* Risk Management |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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