Document Detail

Risk for recurrence of preeclampsia and outcome of subsequent pregnancy in women with preeclampsia in their first pregnancy.
MedLine Citation:
PMID:  22524456     Owner:  NLM     Status:  Publisher    
Abstract Objective: To assess subsequent pregnancy outcome and to identify risk factors for recurrence of preeclampsia (PET) in women with PET in their first pregnancy. Methods: A retrospective cohort study of all nulliparous women diagnosed with PET during the years 1996-2008 (PET group, N=600). Outcome of subsequent pregnancy was compared with a control group of nulliparous women without PET matched by maternal age in a 3:1 ratio (N=1,800). Results: Subsequent pregnancies in the PET group were characterized by a higher rate of preterm delivery at less than 37 and 34 weeks (15.2% vs. 5.7%, P<0.001 and 3.8% vs. 0.8%, P<0.001, respectively), placental abruption (1.7% vs. 0.2%, P=0.004), IUGR (2.8% vs. 0.9%, P=0.016), and PET (5.9% vs. 0.8%, P<0.001). Risk factors for PET and adverse outcome in the subsequent pregnancy included: PET complicated by placental abruption in the index pregnancy (OR=10.8, 95%-CI=1.8-34.6), PET requiring delivery prior to 34 weeks in the index pregnancy (OR=6.5, 95%-CI=1.6-22.5), chronic hypertension (OR=5.3, 95%-CI=1.9-12.7), and maternal age>35 (OR=4.3, 95%-CI=1.2-20.5). Conclusion: PET in the first pregnancy is independently associated with an increased risk for adverse pregnancy outcome and recurrence of PET in the subsequent pregnancy in a manner that is related to the severity of PET in the first pregnancy.
Nir Melamed; Eran Hadar; Yoav Peled; Moshe Hod; Arnon Wiznitzer; Yariv Yogev
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-23
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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