Document Detail

Risk of psychopathology in adolescent offspring of mothers with psychopathology and recurrent depression.
MedLine Citation:
PMID:  23060622     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Offspring of mothers with depression are at heightened risk of psychiatric disorder. Many mothers with depression have comorbid psychopathology. How these co-occurring problems affect child outcomes has rarely been considered.
AIMS: To consider whether the overall burden of co-occurring psychopathology in mothers with recurrent depression predicts new-onset psychopathology in offspring.
METHOD: Mothers with recurrent depression and their adolescent offspring (9-17 years at baseline) were assessed in 2007 and on two further occasions up to 2011. Mothers completed questionnaires assessing depression severity, anxiety, alcohol problems and antisocial behaviour. Psychiatric disorder in offspring was assessed using the Child and Adolescent Psychiatric Assessment.
RESULTS: The number of co-occurring problems in mothers (0, 1 or 2+) predicted new-onset offspring disorder (odds ratio (OR) = 1.80, 95% CI 1.17-2.77, P = 0.007). Rates varied from 15.7 to 34.8% depending on the number of co-occurring clinical problems. This remained significant after controlling for maternal depression severity (OR = 1.73, 95% CI 1.03-2.89, P = 0.040).
CONCLUSIONS: The burden of co-occurring psychopathology among mothers with recurrent depression indexes increased risk of future onset of psychiatric disorder for offspring. This knowledge can be used in targeting preventive measures in children at high risk of psychiatric disorder.
Ruth Sellers; Stephan Collishaw; Frances Rice; Ajay K Thapar; Robert Potter; Becky Mars; Gordon T Harold; Daniel J Smith; Michael J Owen; Nick Craddock; Anita Thapar
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-11
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  202     ISSN:  1472-1465     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-10     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  108-14     Citation Subset:  IM    
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MeSH Terms
Child of Impaired Parents / psychology,  statistics & numerical data*
Depressive Disorder / epidemiology
Epidemiologic Methods
Interview, Psychological
Mental Disorders / epidemiology*
Middle Aged
Mothers / psychology*
Psychiatric Status Rating Scales
Socioeconomic Factors
Grant Support
G9810900//Medical Research Council
Comment In:
Evid Based Ment Health. 2013 Aug;16(3):84   [PMID:  23677708 ]
Br J Psychiatry. 2013 Feb;202:84-5   [PMID:  23377204 ]

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