Document Detail

Risk of preterm delivery in relation to vaginal bleeding in early pregnancy.
MedLine Citation:
PMID:  17207901     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the relationship between vaginal bleeding during early pregnancy and preterm delivery.
METHODS: Study subjects (N=2678) provided information regarding socio-demographic, biomedical, and lifestyle characteristics. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI).
RESULTS: Any vaginal bleeding in early pregnancy was associated with a 1.57-fold increased risk of preterm delivery (95% CI: 1.16-2.11). Vaginal bleeding was most strongly related with spontaneous preterm labor (OR=2.10) and weakly associated with preterm premature rupture of membrane (OR=1.36) and medically induced preterm delivery (OR=1.32). As compared to women with no bleeding, those who bled during the first and second trimesters had a 6.24-fold increased risk of spontaneous preterm labor; and 2-3-fold increased risk of medically induced preterm delivery and preterm premature rupture of membrane, respectively.
CONCLUSION: Vaginal bleeding, particularly bleeding that persists across the first two trimesters, is associated with an increased risk of preterm delivery.
Rydhwana Hossain; Tenecia Harris; Vitool Lohsoonthorn; Michelle A Williams
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-01-04
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  135     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-03-11     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  158-63     Citation Subset:  IM    
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MeSH Terms
Cohort Studies
Obstetric Labor, Premature*
Odds Ratio
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prospective Studies
Socioeconomic Factors
Uterine Hemorrhage*
Grant Support
R01 HD032562/HD/NICHD NIH HHS; R01 HD032562-10/HD/NICHD NIH HHS; R01-HD-32562/HD/NICHD NIH HHS; T37 MD001449/MD/NIMHD NIH HHS; T37 MD001449-09/MD/NIMHD NIH HHS; T37 TW000049/TW/FIC NIH HHS; T37 TW000049-07/TW/FIC NIH HHS; T37-MD001449/MD/NIMHD NIH HHS; T37-TW00049/TW/FIC NIH HHS

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