Document Detail

Risk of premature birth in multifetal pregnancy.
MedLine Citation:
PMID:  10808233     Owner:  NLM     Status:  MEDLINE    
The risk of preterm delivery (< 37 weeks of gestation) is approximately nine times higher in women with multifetal pregnancies than in women with singleton pregnancies. However, it is possible that the risk will vary according to gestational week. To assess the risk of premature birth within 1 week by gestational age among multifetal pregnancies and compare the estimated risk with that of singleton pregnancies, we analyzed 6,036,475 infants born in singleton pregnancies and 90,887 infants born in multifetal pregnancies in Japan (> or =22 weeks) over the 5-year period 1989-1993. An estimate of the risk of birth within 1 week at gestational week n was obtained by dividing the number of infants delivered at gestational week n by the number of infants delivered at or beyond gestational week n. The risk at 22 weeks was 0.9 per 1000 fetuses for singleton pregnancies and 5.0 per 1000 for multifetal pregnancies. The risk remained relatively stable until 27 weeks of gestation, then sharply increased toward 36 weeks of gestation in both singleton and multifetal pregnancies. The odds ratio for birth within 1 week for fetuses of multifetal pregnancies compared with fetuses of singleton pregnancies was 5.9 (95% CI, 5.4-6.5) at 22 weeks of gestation, increasing gradually with increasing gestational age until 33 weeks of gestation (13.7; 95% CI, 13.1-14.2) but declining thereafter to 8.8 (95% CI, 8.6-8.9) at 36 weeks of gestation. Results of data analysis for each year of the 5-year period did not differ substantially.
H Minakami; S Kosuge; H Fujiwara; Y Mori; I Sato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Twin research : the official journal of the International Society for Twin Studies     Volume:  3     ISSN:  1369-0523     ISO Abbreviation:  Twin Res     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-07-25     Completed Date:  2000-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9815819     Medline TA:  Twin Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2-6     Citation Subset:  IM    
Center for Perinatal Medicine, Jichi Medical School Hospital, Minamikawachi-machi, Tochigi, 329-04 Japan.
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MeSH Terms
Confidence Intervals
Gestational Age*
Infant, Newborn
Infant, Premature
Japan / epidemiology
Obstetric Labor, Premature*
Odds Ratio
Pregnancy Outcome
Pregnancy, Multiple*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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