Document Detail


Risk and predictors of cardiovascular disease in psoriasis: a population-based study.
MedLine Citation:
PMID:  23278607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Emerging evidence suggests that severe psoriasis is associated with increased risk of cardiovascular disease. The goal of this study was to examine the risk and predictors of clinical cardiovascular events in psoriasis.
METHODS: We performed a historical cohort and a nested case-cohort study using the population-based resources in Olmsted County, Minnesota. The study population included a population-based incidence cohort of patients with psoriasis first diagnosed between January 1, 1970, and January 1, 2000, and 2678 age- and sex-matched non-psoriasis subjects. Cardiovascular events, including hospitalized myocardial infarction, coronary revascularization procedures, stroke, heart failure, and cardiovascular death.
RESULTS: Psoriasis was associated with an increased risk of myocardial infarction based on diagnostic codes (hazard ratio 1.26; 95% confidence intervals: 1.01, 1.58) but not when the analyses were restricted to validated myocardial infarction (hazard ratio 1.18; 95% confidence intervals: 0.80, 1.74). Psoriasis was not associated with an increased risk of heart failure or cardiovascular death. Traditional cardiovascular risk factors were significantly associated with cardiovascular risk in psoriasis. Each 1% increase in Framingham risk score at psoriasis incidence corresponded with a 5-10% increase in risk of cardiovascular events.
CONCLUSION: In this large incidence cohort of patients with psoriasis representing the full disease severity spectrum, psoriasis was not associated with an increased cardiovascular risk.
Authors:
Hilal Maradit-Kremers; Ross A Dierkhising; Cynthia S Crowson; Murat Icen; Floranne C Ernste; Marian T McEvoy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of dermatology     Volume:  52     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-20     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  32-40     Citation Subset:  IM    
Copyright Information:
© 2013 The International Society of Dermatology.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Cardiovascular Diseases / complications*,  epidemiology,  etiology
Epidemiologic Methods
Female
Humans
Male
Minnesota / epidemiology
Predictive Value of Tests
Prevalence
Psoriasis / complications*,  epidemiology
Risk Factors
Time Factors
Grant Support
ID/Acronym/Agency:
R01 AG034676/AG/NIA NIH HHS; R01 AG034676/AG/NIA NIH HHS; R01 AG034676-47/AG/NIA NIH HHS
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