Document Detail


Risk of obstetric cholestasis in sisters of index patients.
MedLine Citation:
PMID:  11531968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to evaluate the rate of intrahepatic cholestasis of pregnancy in first-degree relatives of index patients. Index patients (n=65) with singleton pregnancies complicated by intrahepatic cholestasis were identified among the women (n=11 984) who gave birth at Kuopio University Hospital in 1994-1998. The pregnancy histories of relatives of 56 index patients were reviewed and the rate of cholestasis in first-degree relatives was compared with that in the general obstetric population. Obstetric cholestasis was experienced by 9% of the parous sisters and 11% of the mothers of the index patients. The risk per delivery was 6% in the first-degree relatives. The rate in the general obstetric population was 0.54%. The odds ratios and 95% confidence intervals were 12.6 (5.6-28.1) for the sisters and 12.2 (6.2-24.2) for the mothers. Obstetric cholestasis clusters within some families and is under strong genetic influence, although the precise genetic pattern remains obscure. The sisters of index patients are at an increased risk of the disorder and may benefit from close obstetric care.
Authors:
M L Eloranta; S Heinonen; T Mononen; S Saarikoski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical genetics     Volume:  60     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-09-04     Completed Date:  2001-09-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  42-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland.
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MeSH Terms
Descriptor/Qualifier:
Cholestasis, Intrahepatic / genetics*
Family Health
Female
Humans
Male
Pedigree
Pregnancy
Pregnancy Complications*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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