Document Detail

Risk of multiple birth associated with in vitro fertilization using donor eggs.
MedLine Citation:
PMID:  11724721     Owner:  NLM     Status:  MEDLINE    
Multiple birth, which is associated with adverse fetal, infant, and maternal outcomes, is increasingly related to the use of in vitro fertilization (IVF). Among women undergoing IVF who use their own eggs, greater maternal age is associated with decreased risk of multiple birth; using donor eggs from younger women may negate this age effect. Data from 6,936 IVF procedures performed in the United States in 1996-1997 on women aged 35-54 years who used donor eggs were analyzed to assess the effect of maternal age, number of embryos transferred, and cryopreservation of extra, nontransferred embryos (an indicator of higher embryo quality) on risk of multiple birth. Greater maternal age did not decrease multiple-birth risk. Rates of multiple birth were related to number of embryos transferred and whether extra embryos had been cryopreserved, and they were high compared with those of IVF patients the same age who had used their own eggs. Among women who had extra embryos cryopreserved, transferring more than two embryos increased multiple-birth risk, with no corresponding increase in the chance for a livebirth. These results highlight the need to consider the age of the donor and embryo quality when making embryo transfer decisions involving use of donor eggs.
M A Reynolds; L A Schieve; G Jeng; H B Peterson; L S Wilcox
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of epidemiology     Volume:  154     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-28     Completed Date:  2002-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1043-50     Citation Subset:  IM    
Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA 30341-3717, USA.
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MeSH Terms
Birth Rate
Chi-Square Distribution
Embryo Transfer / adverse effects*
Fertilization in Vitro
Maternal Age
Middle Aged
Pregnancy Outcome
Pregnancy, High-Risk
Pregnancy, Multiple / statistics & numerical data*
Risk Factors
United States

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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