| Risk markers of future microalbuminuria and hypertension based on clinical and morphological parameters in young type 1 diabetes patients. | |
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MedLine Citation:
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PMID: 19761528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Nephropathy is a severe complication of type 1 diabetes and develops in 30% of patients. Currently, it is not possible to identify young patients at risk prior to the development of microalbuminuria (MA) and/or hypertension (HT). OBJECTIVE: To study predictors of MA and/or HT in young normoalbuminuric (NA) patients with type 1 diabetes. SUBJECTS AND Methods: Forty-six NA and normotensive (NT) type 1 diabetes patients, regularly followed since onset with checks on metabolic control, kidney function, and MA, were investigated with kidney biopsies and 24-h ambulatory blood pressure measurements (ABPMs) after 10.6 yr of diabetes. The patients were followed another six and a half years with regard to the development of MA and HT. RESULTS: Fifteen patients developed MA and/or HT during follow-up. The strongest risk markers were poor metabolic control after puberty, high day-time systolic blood pressure (BP), and increased BMT at 10 yr, which explained 62% of the outcome for MA and/or HT at 17 yr duration with 77% sensitivity and 65% specificity. The threshold values were long-term postpubertal HbA(1c) > 8.2%, day-time systolic BP > 130 mmHg, and BMT > 490 nm/1.73 m(2). CONCLUSIONS: Normoalbuminuric and NT patients at risk of developing MA and HT could be identified and might benefit from an early start of antihypertensive therapy and improvement of metabolic control. |
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Authors:
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Nina E S S Perrin; T Torbjörnsdotter; Georg A Jaremko; Ulla B Berg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric diabetes Volume: 11 ISSN: 1399-5448 ISO Abbreviation: Pediatr Diabetes Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100939345 Medline TA: Pediatr Diabetes Country: Denmark |
Other Details:
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Languages: eng Pagination: 305-13 Citation Subset: IM |
Affiliation:
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Division of Pediatrics, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. Nina.Perrin@karolinska.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Albuminuria / diagnosis*, etiology Biological Markers / blood Blood Pressure Monitoring, Ambulatory Child Diabetes Mellitus, Type 1 / complications*, pathology, physiopathology Diabetic Nephropathies / diagnosis*, etiology Follow-Up Studies Hemoglobin A, Glycosylated / analysis Humans Hypertension / diagnosis*, etiology Kidney / physiopathology Middle Aged Risk Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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