| Risk of lymphoma associated with combination anti-tumor necrosis factor and immunomodulator therapy for the treatment of Crohn's disease: a meta-analysis. | |
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MedLine Citation:
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PMID: 19558997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Although anti-tumor necrosis factor (TNF) therapy can effectively treat Crohn's disease (CD), there is concern that it might increase the risk of non-Hodgkin's lymphoma (NHL). A meta-analysis was performed to determine the rate of NHL in adult CD patients who have received anti-TNF therapy and to compare this rate with that of a population-based registry and a population of CD patients treated with immunomodulators. METHODS: MEDLINE, EMBASE, Cochrane Collaboration, and Web of Science were searched. Inclusion criteria included randomized controlled trials, cohort studies, or case series reporting on anti-TNF therapy in adult CD patients. Standardized incidence ratios (SIR) were calculated by comparing the pooled rate of NHL with the expected rate of NHL derived from the Surveillance Epidemiology & End Results (SEER) database and a meta-analysis of CD patients treated with immunomodulators. RESULTS: Twenty-six studies involving 8905 patients and 21,178 patient-years of follow-up were included. Among anti-TNF treated subjects, 13 cases of NHL were reported (6.1 per 10,000 patient-years). The majority of these patients had previous immunomodulator exposure. Compared with the expected rate of NHL in the SEER database (1.9 per 10,000 patient-years), anti-TNF treated subjects had a significantly elevated risk (SIR, 3.23; 95% confidence interval, 1.5-6.9). When compared with the NHL rate in CD patients treated with immunomodulators alone (4 per 10,000 patient-years), the SIR was 1.7 (95% confidence interval, 0.5-7.1). CONCLUSIONS: The use of anti-TNF agents with immunomodulators is associated with an increased risk of NHL in adult CD patients, but the absolute rate of these events remains low and should be weighed against the substantial benefits associated with treatment. |
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Authors:
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Corey A Siegel; Sadie M Marden; Sarah M Persing; Robin J Larson; Bruce E Sands |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural Date: 2009-01-24 |
Journal Detail:
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Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Volume: 7 ISSN: 1542-7714 ISO Abbreviation: Clin. Gastroenterol. Hepatol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-04 Completed Date: 2009-09-28 Revised Date: 2012-02-16 |
Medline Journal Info:
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Nlm Unique ID: 101160775 Medline TA: Clin Gastroenterol Hepatol Country: United States |
Other Details:
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Languages: eng Pagination: 874-81 Citation Subset: IM |
Affiliation:
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Dartmouth-Hitchcock IBD Center and Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, Massachusetts, USA. corey.a.siegel@hitchcock.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Crohn Disease / complications*, drug therapy* Female Humans Immunologic Factors / adverse effects*, therapeutic use* Incidence Lymphoma / epidemiology* Male Middle Aged Risk Factors* Tumor Necrosis Factor-alpha / antagonists & inhibitors* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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K23 DK078678-02/DK/NIDDK NIH HHS; K23 DK078678-05/DK/NIDDK NIH HHS; K23DK078678/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunologic Factors; 0/TNF protein, human; 0/Tumor Necrosis Factor-alpha |
| Comments/Corrections | |
Comment In:
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Clin Gastroenterol Hepatol. 2009 Oct;7(10):1139
[PMID:
19465159
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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