Document Detail

Risk of gastric injury with enteric- versus nonenteric-coated aspirin.
MedLine Citation:
PMID:  11816246     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate through clinical trials the risk of various aspirin preparations on the gastric mucosa. DATA SOURCES: Articles reporting clinical research were accessed through MEDLINE (1980-November 1998). Key search terms included enteric-coated aspirin, buffered aspirin, and gastrointestinal (GI) bleeding. DATA SYNTHESIS: Aspirin products are known to cause GI bleeding. Enteric-coated aspirin may provide an additional protective effect on gastric mucosa compared with buffered aspirin. An evaluation of studies comparing various aspirin preparations and the risk of gastric mucosal injury was conducted. CONCLUSIONS: For long-term use, enteric-coated aspirin may provide a safer alternative than buffered aspirin; however, further studies are necessary.
Dalia W Banoob; William W McCloskey; William Webster
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  36     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-30     Completed Date:  2002-07-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Pharmacy Department, Saint Joseph's Hospital, Tampa, FL, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*,  adverse effects*
Aspirin / administration & dosage*,  adverse effects*
Case-Control Studies
Randomized Controlled Trials as Topic
Risk Assessment
Stomach Ulcer / chemically induced*,  epidemiology*
Tablets, Enteric-Coated
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Tablets, Enteric-Coated; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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