| Risk factors and underlying mechanisms for venous stasis syndrome: a population-based case-control study. | |
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MedLine Citation:
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PMID: 19808719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Venous stasis syndrome may complicate deep vein thrombosis (DVT; i.e. post-phlebitic syndrome), but, in most cases, venous stasis syndrome is not post-phlebitic. The objective of this study was to determine the risk factors (including prior DVT) for venous stasis syndrome, and to assess venous outflow obstruction and venous valvular incompetence as possible mechanisms for venous stasis syndrome. This was a case-control study nested within a population-based inception cohort. The study population consisted of 232 Olmsted County, MN residents with a first lifetime venous thromboembolism (VTE) and 133 residents without VTE. Measurements included a questionnaire and physical examination for venous stasis syndrome; strain gauge outflow plethysmography, venous continuous wave Doppler ultrasonography and passive venous drainage and refill testing for venous outflow obstruction and venous valvular incompetence. Altogether, 161 (44%), 43 (12%), and 136 (38%) subjects respectively, had venous stasis syndrome, venous outflow obstruction and venous valvular incompetence. Independent risk factors for venous stasis syndrome included increasing patient age and body mass index (BMI), prior DVT, longer time interval since DVT, and varicose veins. Both venous outflow obstruction (p = 0.003) and venous valvular incompetence (p < 0.0001) were strongly associated with venous stasis syndrome. Increasing age and prior DVT were significantly associated with venous outflow obstruction, while prior DVT, varicose veins and venous stasis syndrome diagnosed prior to the incident DVT were significantly associated with venous valvular incompetence. The risks of venous outflow obstruction, venous valvular incompetence and venous stasis syndrome were higher with left leg DVT. In conclusion, increasing patient age and BMI, prior DVT (particularly left leg DVT), longer time interval since DVT and varicose veins are independent risk factors for venous stasis syndrome. Venous stasis syndrome related to DVT is due to venous outflow obstruction and venous valvular incompetence, while venous stasis syndrome related to older age and to varicose veins is due to venous outflow obstruction and to venous valvular incompetence, respectively. |
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Authors:
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Aneel A Ashrani; Marc D Silverstein; Brian D Lahr; Tanya M Petterson; Kent R Bailey; L Joseph Melton; John A Heit |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Vascular medicine (London, England) Volume: 14 ISSN: 1358-863X ISO Abbreviation: Vasc Med Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-07 Completed Date: 2009-12-18 Revised Date: 2011-03-01 |
Medline Journal Info:
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Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
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Languages: eng Pagination: 339-49 Citation Subset: IM |
Affiliation:
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Division of Hematology, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. ashrani.aneel@mayo.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Body Mass Index Case-Control Studies Female Humans Logistic Models Male Middle Aged Minnesota Odds Ratio Plethysmography Population Surveillance Postthrombotic Syndrome / etiology*, physiopathology Questionnaires Regional Blood Flow Risk Assessment Risk Factors Ultrasonography, Doppler Varicose Veins / complications, physiopathology Venous Thrombosis / complications, physiopathology Venous Valves / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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AR30582/AR/NIAMS NIH HHS; HL66216/HL/NHLBI NIH HHS; HL69203/HL/NHLBI NIH HHS; HL83141/HL/NHLBI NIH HHS; HL83797/HL/NHLBI NIH HHS; K12 HL083797-04/HL/NHLBI NIH HHS; K23 HL069203-06/HL/NHLBI NIH HHS; R01 AR030582-34/AR/NIAMS NIH HHS; R01 HL066216-07/HL/NHLBI NIH HHS; R01 HL083141-04/HL/NHLBI NIH HHS; RR9457/RR/NCRR NIH HHS |
| Comments/Corrections | |
Erratum In:
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Vasc Med. 2010 Feb;15(1):79 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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