Document Detail

Risk factors, treatments, and outcomes associated with prolonged hyperemesis gravidarum.
MedLine Citation:
PMID:  21916750     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify factors associated with prolonged Hyperemesis Gravidarum (HG).
STUDY DESIGN: About 395 women completed a survey regarding pre-existing conditions, treatments and outcomes. Responses were compared using two-sided t-tests or the F-test.
RESULTS: Participants with prolonged HG are slightly younger and weigh more. Pre-existing factors associated with prolonged HG include allergies and a restrictive diet. Prolonged HG is associated with hematemesis, dizziness, fainting and antiemetic treatment. Following pregnancy, those with prolonged HG reported more posttraumatic stress, motion sickness, muscle weakness and infants with irritability, severe colic and growth restriction.
CONCLUSION: Multiple pre-existing conditions and poor maternal and infant outcomes were associated with prolonged HG. The most significant condition prior to pregnancy was allergies suggesting a possible autoimmune component affecting duration of HG. In addition, the most significant lifestyle choice linked to prolonged HG was a restrictive diet. Future research is needed to determine whether a change in diet prior to pregnancy may lead to a shorter duration of HG and its associated outcomes.
Patrick M Mullin; ChunYu Ching; Frederic Schoenberg; Kimber MacGibbon; Roberto Romero; T Murphy Goodwin; Marlena S Fejzo
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2011-09-15
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-14     Completed Date:  2012-09-21     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  632-6     Citation Subset:  IM    
Keck School of Medicine, University of Southern California, Department of Maternal-Fetal Medicine, Los Angeles, CA 90095, USA.
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MeSH Terms
Diet / adverse effects,  statistics & numerical data
Diet Therapy / methods,  utilization
Fetal Development / physiology
Hyperemesis Gravidarum / complications,  epidemiology*,  etiology*,  therapy*
Infant, Newborn
Middle Aged
Pregnancy Complications / epidemiology,  etiology
Pregnancy Outcome / epidemiology*
Risk Factors
Time Factors
Young Adult
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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