Document Detail

Risk factors for sensorineural hearing loss in extremely premature infants.
MedLine Citation:
PMID:  7576889     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify potentially preventable risk factors for sensorineural hearing loss (SNHL) in extremely premature infants. METHODOLOGY: A case control study of survivors with gestational age (GA) < 28 weeks or birthweight (BW) < 1000 g using data collected prospectively in our Neonatal Intensive Care Unit database. Each subject with bilateral SNHL > 40 dB was matched according to GA, BW and sex with two controls who had neither sensorineural nor conductive hearing loss. RESULTS: Infants with SNHL had increased mean (+/- s.d.) days ventilated (53 +/- 21 vs 37 +/- 23 days, P = 0.006) and in oxygen (107 +/- 44 vs 69 +/- 28 days, P = 0.02) compared with controls. The risk for SNHL was increased for infants who spent > 90 days in oxygen (OR 4.0 [95% CI 1.1-15.6]), had maximum FiO2 > 0.90 (5.6 [1.2-26.9]), minimum plasma Na < 125 mmol/L (5.6 [1.1-27.8] or maximum pH > 7.60 (5.6 [1.1-89.0]). Neither maximum serum bilirubin nor exposure to ototoxic drugs was associated with SNHL. CONCLUSIONS: Avoidance of severe hyponatraemia and extreme alkalosis, as well as use of surfactant to minimize the severity of hyaline membrane disease, may result in a decreased incidence of SNHL in extremely premature infants.
G I Leslie; M B Kalaw; J R Bowen; J D Arnold
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  31     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-12     Completed Date:  1995-12-12     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  312-6     Citation Subset:  IM    
Department of Neonatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
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MeSH Terms
Alkalosis / complications
Analysis of Variance
Case-Control Studies
Hearing Loss, Sensorineural / etiology,  prevention & control*
Hyperbilirubinemia / complications
Hyponatremia / drug therapy
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight*
Logistic Models
Odds Ratio
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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