Document Detail

Risk factors of retinopathy of prematurity in premature infants weighing less than 1600 g.
MedLine Citation:
PMID:  15731992     Owner:  NLM     Status:  MEDLINE    
There are many risk factors contributing to retinopathy of prematurity (ROP). Some are still controversial, including the use of glucocorticoid and intraventricular hemorrhage. Hence, a retrospective study was performed to evaluate the association between the suspected risk factors and ROP in a medical center in southern Taiwan. One hundred fifty-nine infants with birth body weight < 1600 g admitted to our neonatal intensive care unit before the 29th day of life were enrolled into this study. Clinical data were analyzed by means of logistic regression. The prevalence of ROP in all infants (birthweight < 1600 g) is 36.48% (58 of 159) and 59.46% (22 of 37) in extremely low birthweight infants (birthweight < or = 1000 g). One infant with gestational age 32 weeks and birthweight 1420 g developed stage III ROP. Logistic regression revealed six factors to be significant variables. Birthweight < or = 1000 g, intraventricular hemorrhage, sepsis, and use of glucocorticoid or dopamine were risk factors associated with higher incidence of ROP. Supplementation of vitamin E was shown to relate to lower incidence of ROP. This study confirms several risk factors recognized in previous statistical analyses. Sepsis is the most significant factor contributing to ROP. Vitamin E was proven to be effective in prophylaxis of development of ROP. The possibility of development of ROP could not be excluded in infants with gestational age > 32 weeks.
Po-Mai Liu; Po-Chiung Fang; Chung-Bin Huang; His-Kung Kou; Mei-Yung Chung; Yi-Hsin Yang; Ching-Hung Chung
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  22     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-25     Completed Date:  2005-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-20     Citation Subset:  IM    
Department of Pediatrics, Division of Neonatology, Chang Gung Children's Hospital, Kaohsiung, Taiwan.
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MeSH Terms
Blood Transfusion / statistics & numerical data
Cardiotonic Agents / therapeutic use
Dopamine / therapeutic use
Gestational Age
Glucocorticoids / therapeutic use
Infant, Newborn
Infant, Very Low Birth Weight*
Intracranial Hemorrhages / epidemiology
Logistic Models
Pulmonary Surfactants / therapeutic use
Respiration, Artificial / statistics & numerical data
Retinopathy of Prematurity / epidemiology*
Retrospective Studies
Risk Factors
Sepsis / epidemiology
Taiwan / epidemiology
Vitamin E / therapeutic use
Reg. No./Substance:
0/Cardiotonic Agents; 0/Glucocorticoids; 0/Pulmonary Surfactants; 1406-18-4/Vitamin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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