| Risk factors for pulmonary hypertension in patients with β thalassemia intermedia. | |
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MedLine Citation:
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PMID: 22075289 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Pulmonary hypertension (PHT) is a common yet poorly understood complication of β thalassemia intermedia (TI). METHODS: We herein evaluated risk factors for PHT in TI, through comparing 64 TI patients with evidence of PHT by symptomatology and echocardiography (Group I) to age- and sex-matched TI patients without PHT (Group II). Retrieved data included demographics, laboratory parameters, clinical characteristics, and received treatments that may influence PHT development; and reflected the period prior to PHT occurrence in Group I. RESULTS: The mean age of Group I patients at development of PHT was 37.3±10.6years; with 44% being males. Among studied parameters, Group I patients were more likely to be splenectomized (4.9-times), transfusion-naive (3.5-times); hydroxyurea-naive (2.6-times), or iron chelation-naive (2.3-times); and have nucleated red blood cell count ≥300×10(6)/l (2.59-times) or a previous history of thromboembolic events (3.69-times). CONCLUSION: TI patients who eventually develop PHT may be identified early on by being splenectomized, having high nucleated red blood cell counts and a previous history of thromboembolism. Prospective clinical trials that evaluate the efficacy, safety, and cost effectiveness of transfusion, iron chelation, and hydroxyurea therapy in preventing PHT in TI are invited. |
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Authors:
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Mehran Karimi; Khaled M Musallam; Maria Domenica Cappellini; Shahina Daar; Amal El-Beshlawy; Khawla Belhoul; Mohamed-Salaheldin Saned; Sally Temraz; Suzanne Koussa; Ali T Taher |
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Publication Detail:
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Type: Journal Article Date: 2011-06-29 |
Journal Detail:
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Title: European journal of internal medicine Volume: 22 ISSN: 1879-0828 ISO Abbreviation: Eur. J. Intern. Med. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9003220 Medline TA: Eur J Intern Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 607-10 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pediatrics, Thrombosis and Hemostasis Unit, Hematology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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