Document Detail


Risk factors for the presence of high-level shedders of Escherichia coli O157 on Scottish farms.
MedLine Citation:
PMID:  17360845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Escherichia coli O157 infections are the cause of sporadic or epidemic cases of often bloody diarrhea that can progress to hemolytic uremic syndrome (HUS), a systematic microvascular syndrome with predominantly renal and neurological complications. HUS is responsible for most deaths associated with E. coli O157 infection. From March 2002 to February 2004, approximately 13,000 fecal pat samples from 481 farms with finishing/store cattle throughout Scotland were examined for the presence of E. coli O157. A total of 441 fecal pats from 91 farms tested positive for E. coli O157. From the positive samples, a point estimate for high-level shedders was identified using mixture distribution analysis on counts of E. coli O157. Models were developed based on the confidence interval surrounding this point estimate (high-level shedder, greater than 10(3) or greater than 10(4) CFU g(-1) feces). The mean prevalence on high-level-shedding farms was higher than that on low-level-shedding farms. The presence of a high-level shedder on a farm was found to be associated with a high proportion of low-level shedding, consistent with the possibility of a higher level of transmission. Analysis of risk factors associated with the presence of a high-level shedder on a farm suggested the importance of the pathogen and individual host rather than the farm environment. The proportion of high-level shedders of phage 21/28 was higher than expected by chance. Management-related risk factors that were identified included the type of cattle (female breeding cattle) and cattle stress (movement and weaning), as opposed to environmental factors, such as water supply and feed.
Authors:
Margo E Chase-Topping; Iain J McKendrick; Michael C Pearce; Peter MacDonald; Louise Matthews; Jo Halliday; Lesley Allison; Dave Fenlon; J Christopher Low; George Gunn; Mark E J Woolhouse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-14
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  45     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-07     Completed Date:  2007-06-13     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1594-603     Citation Subset:  IM    
Affiliation:
Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom. margo.chase@ed.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Agriculture
Animals
Cattle
Cattle Diseases / epidemiology,  microbiology*
Data Collection
Escherichia coli Infections / epidemiology,  microbiology,  veterinary*
Escherichia coli O157 / isolation & purification*
Feces / microbiology
Questionnaires
Risk Factors
Scotland / epidemiology
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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