Document Detail

Risk factors for premature atherosclerosis.
MedLine Citation:
PMID:  10329522     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: to investigate the prevalence of risk factors in patients with premature atherosclerosis. DESIGN: retrospective controlled study. MATERIALS: 135 consecutive patients with premature atherosclerosis </= 55 years (group I) were investigated. A control group comprised 107 consecutive patients >/= 65 years (group II) with atherosclerosis. Statistical analysis was performed with Chi-squared test and logistic regression analysis. RESULTS: group I versus group II: diabetes 11% vs. 27% (p=0.001), smoking 84% vs. 67% (p=0.002), hypertension 36% vs. 58% (p=0.001), hypercholesterolaemia 47% vs. 34% (p=0.04), family history of cardiovascular disease 53% vs. 42% (p=0.08). In group I hyperhomocysteinaemia was present in 24 of the 108 patients tested, anticardiolipin antibodies were present in four of the 34 tested and coagulation abnormalities were found in four of the 22 patients tested. CONCLUSION: the difference in the prevalence of the different risk factors between the two groups suggests that either certain risk factors are more likely to cause premature atherosclerosis, or that other risk factors must be present in addition to the known risk factors in order to induce premature atherosclerosis.
V J Leijdekkers; A C Vahl; J J Leenders; P C Huijgens; R O Gans; J A Rauwerda
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  17     ISSN:  1078-5884     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-07-23     Completed Date:  1999-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  394-7     Citation Subset:  IM    
Copyright Information:
Copyright 1999 W.B. Saunders Company Ltd.
Department of Vascular Surgery, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands.
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MeSH Terms
Age Distribution
Angiography / statistics & numerical data
Arteriosclerosis / epidemiology*,  radiography
Chi-Square Distribution
Confidence Intervals
Logistic Models
Middle Aged
Odds Ratio
Retrospective Studies
Risk Factors

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