Document Detail

Risk factors for persistence of pulmonary arterial branch stenosis in neonates and young infants.
MedLine Citation:
PMID:  11207997     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pulmonary arterial branch stenosis (PBS) in neonates is considered to be transient. However, PBS has been found not only in neonates, but also in young infants. Among these patients, we encountered several patients whose PBS was still present after the age of 1 year. METHODS: To clarify the natural history of PBS in neonates and young infants, we retrospectively reviewed the records of 103 patients diagnosed with PBS in the neonatal period and early infancy. RESULTS: The PBS findings were improved in all patients. Pulmonary arterial branch stenosis disappeared in 94 patients by the age of 1 year (group A), but persisted after I year of age in nine patients (group B). Group B patients had a significantly lower mean birth weight and greater deltavelocity (the difference in the peak flow velocity between the main pulmonary artery and stenotic branch) at diagnosis than group A patients. Incidences of low birth weight (< 2,500 g) and deltavelocity above 1.2 m/s were significantly higher in group B than group A patients. There was no significant difference in the frequency of premature infants (gestational age < 36 weeks) between the groups, suggesting that intrauterine growth retardation may be related to developmental abnormalities of the pulmonary arterial branch. CONCLUSIONS: All cases of PBS in neonates and young infants were improved. However, PBS persisted in some patients after the age of 1 year. Low birth weight and deltavelocity above 1.2 m/s are risk factors for persistent PBS. Pulmonary arterial branch stenosis was not present after the age of 1 year in 62 of 63 patients without either of these risk factors.
Y Nomura; M Nakamura; Y Kono; T Fukushige; A Shimago; J Kamimura; J I Nishi; M Yoshinaga; K Miyata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  43     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-10     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  36-41     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, Kagoshima University, Japan.
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MeSH Terms
Age Factors
Blood Flow Velocity
Disease Progression
Infant, Low Birth Weight
Infant, Newborn
Pulmonary Artery / abnormalities*
Pulmonary Valve Stenosis / physiopathology*,  ultrasonography
Retrospective Studies
Risk Factors

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