Document Detail

Risk factors for periventricular-intraventricular hemorrhage in premature infants.
MedLine Citation:
PMID:  20191041     Owner:  NLM     Status:  MEDLINE    
Periventricular-intraventricular hemorrhage (PV-IVH) is a major cause of neurological disabilities in preterm newborns. This study aimed to determine the perinatal factors associated with PV-IVH. We conducted a retrospective case-control study from preterm infants born at < or =34 weeks of gestation and admitted to Neonatal Intensive Care Units of Seoul National University Children's Hospital and Seoul National University Bundang Hospital between June 2003 and December 2007. Neonates with no cranial sonographic data or infants transferred from other centers after three days of age were excluded. Of 1,044 eligible subjects, 59 infants with PV-IVH grade 2, 3, and 4 were allocated to the case group. The control group consisted of 118 infants without PV-IVH who were matched for gestational age and birth weight to each case of PV-IVH. At the multivariate logistic regression model, metabolic acidosis (odds ratio [OR]: 6.94; 95% confidence interval [CI]: 1.12-43.23) and use of inotropes (OR: 3.70; 95% CI: 1.16-11.84) were associated with an increased risk of PV-IVH. Maternal use of antenatal corticosteroids decreases the risk of PV-IVH (OR: 0.36; 95% CI: 0.14-0.92).
Ju Young Lee; Han Suk Kim; Euiseok Jung; Eun Sun Kim; Gyu Hong Shim; Hyun Joo Lee; Jin A Lee; Chang Won Choi; Ee-Kyung Kim; Beyong Il Kim; Jung-Hwan Choi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-17
Journal Detail:
Title:  Journal of Korean medical science     Volume:  25     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-05-18     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  418-24     Citation Subset:  IM    
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
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MeSH Terms
Acidosis / complications
Birth Weight
Cardiotonic Agents / adverse effects
Case-Control Studies
Cerebral Hemorrhage / etiology*,  pathology
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / etiology*,  pathology
Odds Ratio
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Cardiotonic Agents

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