Document Detail

Risk factors for osteoporosis in Caucasian patients with moderate chronic obstructive pulmonary disease: a case control study.
MedLine Citation:
PMID:  22426499     Owner:  NLM     Status:  MEDLINE    
The prevalence of osteoporosis is high in chronic obstructive pulmonary disease (COPD) patients. The gold standard for the diagnosis of osteoporosis is bone mineral density (BMD) measurements as assessed by dual energy absorptiometry (DXA) scanning as well as vertebral fractures as assessed by instant vertebral assessment (IVA). The aim of this study was to compare COPD GOLD II patients (that is, patients with moderate COPD, stage II, according to the GOLD classification) with osteoporosis (cases) to COPD GOLD II patients without osteoporosis (controls) to identify risk factors for osteoporosis. The diagnosis of osteoporosis was based on BMD and vertebral fractures. Cases (n=49) were matched for gender, age and forced expiratory volume in the first second to controls (n=49). We assessed pulmonary function, body composition, vitamin D, emphysema score (by high-resolution computer tomography), medical history and medication use in all patients. Variables that were significantly different between the cases and controls were included in a logistic regression analysis. COPD patients with osteoporosis had a significantly lower body mass index (BMI) and higher residual volume as the percentage of total lung capacity (RV%TLC) compared to COPD patients without osteoporosis. Decreasing BMI and increasing RV%TLC increased the odds ratio for osteoporosis. Overweight and obese BMI values were protective for osteoporosis. Screening for osteoporosis should be performed even in moderate COPD patients, especially in those with a low BMI and/or a high RV%TLC.
Lidwien Graat-Verboom; Frank W J M Smeenk; Ben E E M van den Borne; Martijn A Spruit; Astrid B Donkers-van Rossum; Renske P M Aarts; Emiel F M Wouters
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Publication Detail:
Type:  Journal Article     Date:  2012-03-09
Journal Detail:
Title:  Bone     Volume:  50     ISSN:  1873-2763     ISO Abbreviation:  Bone     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-15     Completed Date:  2012-09-13     Revised Date:  2013-02-07    
Medline Journal Info:
Nlm Unique ID:  8504048     Medline TA:  Bone     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1234-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Respiratory Medicine, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
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MeSH Terms
Body Mass Index
Bone Density
Case-Control Studies
European Continental Ancestry Group
Forced Expiratory Volume
Logistic Models
Middle Aged
Obesity / complications
Odds Ratio
Osteoporosis / etiology*,  pathology,  physiopathology,  prevention & control
Overweight / complications
Pulmonary Disease, Chronic Obstructive / complications*,  pathology,  physiopathology
Risk Factors
Total Lung Capacity
Comment In:
Bone. 2013 Feb;52(2):711   [PMID:  22975111 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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